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Patients with Bardet-Biedl syndrome show increased levels of leptin and leptin resistance, secondary to changes in leptin receptor trafficking secondary to ciliary dysfunction [45, 46]

Against that backdrop, the magnitude of weight loss observed in GLP-1 clinical trials stands out as historically atypical for pharmacologic obesity treatments

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Many of these side effects are a direct result of its mechanism of action, and patients are not advised to initiate on a high dose of Ozempic

If redness spreads beyond 2 inches from the injection site, lasts more than 48 hours, or is accompanied by warmth, swelling, or drainage, contact a healthcare provider